Short answer:
If Mac Mail Preferences appears blank, reset the Mail app by removing local Mail data and containers. This forces macOS to rebuild the settings.
Summary: If you open Mail > Preferences and see a blank window with no options, the Mail app configuration may be corrupted. Follow the steps below to reset the app and restore the Preferences view.
If you see a blank Preferences window like below, follow the steps to resolve it:

Steps to fix blank Preferences in Mac Mail
- Quit the Mail app completely
Make sure Mail is fully closed. Open Activity Monitor and confirm that Mail is not running. - Open Finder and go to:
Go > Go to Folder - Rename the following folder:
~/Library/Mail
- Delete the following folder:
~/Library/Containers/com.apple.mail
- Reopen the Mail app.
What happens next
Apple Mail will automatically re-download your mailbox data (IMAP folders) and recreate the Preferences configuration.
Cleanup
After confirming that Mail is working correctly, you can delete the renamed ~/Library/Mail folder.
Next steps
Return to Mail > Preferences and verify that the Signatures section is now accessible.
